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RetaRevolution

Tracker

TRIUMPH phase 3 trial tracker

Enrollment, status, results and news for retatrutide's TRIUMPH-1, -2 and -3 trials. Retatrutide is investigational and not FDA-approved.
Registry data retrieved from ClinicalTrials.gov on 2026-10-11. Topline sponsor announcements are not peer-reviewed and are labeled separately. Separate trials, different populations — not head-to-head comparisons or individual predictions. RetaRevolution is not affiliated with Eli Lilly and does not sell or source retatrutide.

Enrollment & status

TRIUMPH-1

Completed

A Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight

2,335

Actual enrollment

Start
2023-07-10
Primary completion
2026-04-06
Completion
2026-04-30
Registry updated
2026-08-21
NCT05929066

TRIUMPH-2

Completed

A Study of Retatrutide (LY3437943) in Participants With Type 2 Diabetes Mellitus Who Have Obesity or Overweight

1,152

Actual enrollment

Start
2023-07-11
Primary completion
2026-06-16
Completion
2026-06-16
Registry updated
2026-07-30
NCT05929079

TRIUMPH-3

Completed

A Study of Retatrutide (LY3437943) in Participants With Obesity and Cardiovascular Disease

1,946

Actual enrollment

Start
2023-05-30
Primary completion
2026-04-16
Completion
2026-05-14
Registry updated
2026-07-30
NCT05882045

Reported results (mean % body-weight change)

TRIUMPH-1

Peer-reviewed · verified
12 mg-25.0%
Placebo-3.9%

TRIUMPH-1 (NEJM 2026), week 80 · physician-verified

TRIUMPH-2

Topline only — not peer-reviewed

Evidence under physician review

No peer-reviewed, physician-verified results yet.

TRIUMPH-3

Topline only — not peer-reviewed

Evidence under physician review

No peer-reviewed, physician-verified results yet.

News updates

  1. · Peer-reviewed · TRIUMPH-1

    TRIUMPH-1 results published in NEJM (online ahead of print)

    Peer-reviewed week-80 results published. Verified figures are shown in the results section above.

    N Engl J Med, PMID 42814954

  2. · Registry · TRIUMPH-1

    TRIUMPH-1 registry record updated

    Status Completed; actual enrollment 2,335 (paper reports 2,339 randomized — discrepancy pending physician review).

    ClinicalTrials.gov

  3. · Registry · TRIUMPH-2, TRIUMPH-3

    TRIUMPH-2 and TRIUMPH-3 registry records updated

    Both listed as Completed; actual enrollment 1,152 and 1,946.

    ClinicalTrials.gov

  4. · Sponsor topline · TRIUMPH-2, TRIUMPH-3

    Sponsor announces topline TRIUMPH-2 and TRIUMPH-3 results

    Topline only, not peer-reviewed. Figures withheld until physician review of a peer-reviewed source.

    Eli Lilly press release

Full study details on the Retatrutide page · Retatrutide FAQ